Richard Unwin D. Analysis of Protein Post-Translational Modifications by Mass Spectrometry

Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

12581.12 RUR

/ / похожие


Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient

Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

16934.89 RUR

/ / похожие


Friedrich Lottspeich Microcharacterization of Proteins

Proteomics – the analysis of the whole set of proteins and their functions in a cell – is based on the revolutionary developments which have been achieved in protein analysis during the last years. The number of finished genome projects is growing and in parallel there is a dramatically increasing need to identify the products of revealed genes. Acting on a micro level modern protein chemistry increases our understanding of biological events by elucidating the relevant structure-function relationships. The second edition of the successful title Microcharacterization of Proteins presents a current overview of modern protein analysis: From sample preparation to sequence analysis, mass spectrometry and bioinformatics it informs about the tools needed in protein research. This makes the book indispensable for everyone involved in proteomics!

16867.89 RUR

/ / похожие


Michael Kinter Protein Sequencing and Identification Using Tandem Mass Spectrometry

How to design, execute, and interpret experiments for protein sequencing using mass spectrometry The rapid expansion of searchable protein and DNA databases in recent years has triggered an explosive growth in the application of mass spectrometry to protein sequencing. This timely and authoritative book provides professionals and scientists in biotechnology research with complete coverage of procedures for analyzing protein sequences by mass spectrometry, including step-by-step guidelines for sample preparation, analysis, and data interpretation. Michael Kinter and Nicholas Sherman present their own high-quality, laboratory-tested protocols for the analysis of a wide variety of samples, demonstrating how to carry out specific experiments and obtain fast, reliable results with a 99% success rate. Readers will get sufficient experimental detail to apply in their own laboratories, learn about the proper selection and operation of instruments, and gain essential insight into the fundamental principles of mass spectrometry and protein sequencing. Coverage includes: Peptide fragmentation and interpretation of product ion spectra Basic polyacrylamide gel electrophoresis Preparation of protein digests for sequencing experiments Mass spectrometric analysis using capillary liquid chromatography Techniques for protein identification by database searches Characterization of modified peptides using tandem mass spectrometry And much more

17617.58 RUR

/ / похожие


Jiskoot Wim Analysis of Aggregates and Particles in Protein Pharmaceuticals

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

13588.03 RUR

/ / похожие


Kevin Downard Mass Spectrometry of Protein Interactions

The authoritative guide to analyzing protein interactions by mass spectrometry Mass spectrometry (MS) is playing an increasingly important role in the study of protein interactions. Mass Spectrometry of Protein Interactionspresents timely and definitive discussions of the diverse range of approaches for studying protein interactions by mass spectrometry with an extensive set of references to the primary literature. Each chapter is written by authors or teams of authors who are international authorities in their fields. This leading reference text: * Discusses the direct detection of protein interactions through electrospray ionization (ESI-MS); ion mobility analysis; and matrix-assisted laser desorption/ionization (MALDI-MS) * Covers the indirect analysis of protein interactions through hydrogen-deuterium exchange (HX-MS); limited proteolysis; cross-linking; and radial probe (RP-MS) * Guides researchers in the use of mass spectrometry in structural biology, biochemistry, and protein science to map and define the huge number and diversity of protein interactions * Reviews the latest discoveries and applications and addresses new and ongoing challenges This is a comprehensive reference for researchers in academia and industry engaged in studies of protein interactions and an excellent text for graduate and postgraduate students.

9085.23 RUR

/ / похожие


Группа авторов Prediction of Protein Structures, Functions, and Interactions

The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. Prediction of Protein Structures, Functions and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. Methods of modeling of individual proteins, prediction of their interactions, and docking of complexes are put in the context of predicting gene ontology (biological process, molecular function, and cellular component) and discussed in the light of their contribution to the emerging field of systems biology. Topics covered include: first steps of protein sequence analysis and structure prediction automated prediction of protein function from sequence template-based prediction of three-dimensional protein structures: fold-recognition and comparative modelling template-free prediction of three-dimensional protein structures quality assessment of protein models prediction of molecular interactions: from small ligands to large protein complexes macromolecular docking integrating prediction of structure, function, and interactions Prediction of Protein Structures, Functions and Interactions focuses on the methods that have performed well in CASPs, and which are constantly developed and maintained, and are freely available to academic researchers either as web servers or programs for local installation. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students working in structural bioinformatics, protein chemistry, structural biology and drug discovery.

17523.87 RUR

/ / похожие


Friedrich Lottspeich Bioanalytics

Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids. The presentation includes frequent cross-references in order to highlight the many connections between different techniques. The book provides a bird´s eye view of the entire subject and enables the reader to select the most appropriate method for any given bioanalytical challenge. This makes the book a handy resource for students and researchers in setting up and evaluating experimental research. The depth of the analysis and the comprehensive nature of the coverage mean that there is also a great deal of new material, even for experienced experimentalists. The following techniques are covered in detail: – Purification and determination of proteins – Measuring enzymatic activity – Microcalorimetry – Immunoassays, affinity chromatography and other immunological methods – Cross-linking, cleavage, and chemical modification of proteins – Light microscopy, electron microscopy and atomic force microscopy – Chromatographic and electrophoretic techniques – Protein sequence and composition analysis – Mass spectrometry methods – Measuring protein-protein interactions – Biosensors – NMR and EPR of biomolecules – Electron microscopy and X-ray structure analysis – Carbohydrate and lipid analysis – Analysis of posttranslational modifications – Isolation and determination of nucleic acids – DNA hybridization techniques – Polymerase chain reaction techniques – DNA sequence and epigenetic modification analysis – Analysis of protein-nucleic acid interactions – Analysis of sequence data – Proteomics, metabolomics, peptidomics and toponomics – Chemical biology

11245.26 RUR

/ / похожие


Yi Pan Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics

An in-depth look at the latest research, methods, and applications in the field of protein bioinformatics This book presents the latest developments in protein bioinformatics, introducing for the first time cutting-edge research results alongside novel algorithmic and AI methods for the analysis of protein data. In one complete, self-contained volume, Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics addresses key challenges facing both computer scientists and biologists, arming readers with tools and techniques for analyzing and interpreting protein data and solving a variety of biological problems. Featuring a collection of authoritative articles by leaders in the field, this work focuses on the analysis of protein sequences, structures, and interaction networks using both traditional algorithms and AI methods. It also examines, in great detail, data preparation, simulation, experiments, evaluation methods, and applications. Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics: Highlights protein analysis applications such as protein-related drug activity comparison Incorporates salient case studies illustrating how to apply the methods outlined in the book Tackles the complex relationship between proteins from a systems biology point of view Relates the topic to other emerging technologies such as data mining and visualization Includes many tables and illustrations demonstrating concepts and performance figures Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics is an essential reference for bioinformatics specialists in research and industry, and for anyone wishing to better understand the rich field of protein bioinformatics.

11999.95 RUR

/ / похожие


Ali Nayfeh H. Perturbation Methods

The Wiley Classics Library consists of selected books that have become recognized classics in their respective fields. With these new unabridged and inexpensive editions, Wiley hopes to extend the life of these important works by making them available to future generations of mathematicians and scientists. Currently available in the Series: T. W. Anderson The Statistical Analysis of Time Series T. S. Arthanari & Yadolah Dodge Mathematical Programming in Statistics Emil Artin Geometric Algebra Norman T. J. Bailey The Elements of Stochastic Processes with Applications to the Natural Sciences Robert G. Bartle The Elements of Integration and Lebesgue Measure George E. P. Box & Norman R. Draper Evolutionary Operation: A Statistical Method for Process Improvement George E. P. Box & George C. Tiao Bayesian Inference in Statistical Analysis R. W. Carter Finite Groups of Lie Type: Conjugacy Classes and Complex Characters R. W. Carter Simple Groups of Lie Type William G. Cochran & Gertrude M. Cox Experimental Designs, Second Edition Richard Courant Differential and Integral Calculus, Volume I RIchard Courant Differential and Integral Calculus, Volume II Richard Courant & D. Hilbert Methods of Mathematical Physics, Volume I Richard Courant & D. Hilbert Methods of Mathematical Physics, Volume II D. R. Cox Planning of Experiments Harold S. M. Coxeter Introduction to Geometry, Second Edition Charles W. Curtis & Irving Reiner Representation Theory of Finite Groups and Associative Algebras Charles W. Curtis & Irving Reiner Methods of Representation Theory with Applications to Finite Groups and Orders, Volume I Charles W. Curtis & Irving Reiner Methods of Representation Theory with Applications to Finite Groups and Orders, Volume II Cuthbert Daniel Fitting Equations to Data: Computer Analysis of Multifactor Data, Second Edition Bruno de Finetti Theory of Probability, Volume I Bruno de Finetti Theory of Probability, Volume 2 W. Edwards Deming Sample Design in Business Research

11432.68 RUR

/ / похожие


Dr Richard Unwin PhD - Research interests | The University ...

My key research interests lie in the analysis protein expression changes which underpin pathogenesis, particularly in neurodegenerative diseases. The aim of this work is to dissect molecular events which are involved in disease development, even in cases where disease is subclinical, to provide information on key processes which contribute to the development of pathology.

Dr Richard Unwin PhD | The University of Manchester

Richard obtained a BSc. in Biology, and an MSc. (Distinction) in Oncology from Nottingham University before completing his PhD in Leeds, applying proteomics to study renal cell carcinoma and developing methods for identifying tumour markers and antigens. Moving to Manchester for his post-Doc, he developed methods for the proteomic analysis of leukaemic and normal haematopoietic cell and stem ...

Unwind Critical Essays -

Unwind Homework Help Questions. What are some real-world conflicts in the book Unwind. In his novel, Unwind, Neal Shusterman addresses numerous real-life, real-world issues.

Richard III: Act I, scene i | SparkNotes

Richard’s side, the House of York, eventually wins, and Richard’s oldest brother, Edward, is now King Edward IV. This knowledge of the recent civil war helps us make sense of the opening lines, spoken by Richard: “Now is the winter of our discontent / Made glorious summer by this son of York; / And all the clouds that loured upon our homes / In the deep bosom of the ocean buried” (I.i ...

Richard II - CliffsNotes

Character Analysis Richard II As a king, Richard is supposedly divine and all powerful; as a man, he is an ordinary mortal and prey to his own weaknesses. The private tragedy of the play, for Richard, is in his being forced to face this duality. Shakespeare demonstrates that Richard is perhaps temperamentally not fit for the role which history would have him play. His decisions as a monarch ...

Remembering to Let Yourself Unwind | by Richard K. Yu | Medium

Remembering to Let Yourself Unwind. Richard K. Yu. Follow. Dec 30, 2017 · 2 min read. Staying true to yourself is one of the most important things you can do. Photo Credit: User 7854. I t’s ...

Applied Multivariate Statistical Analysis (6th Edition ...

Richard A. Johnson, Dean W. Wichern This market leader offers a readable introduction to the statistical analysis of multivariate observations. Gives readers the knowledge necessary to make proper interpretations and select appropriate techniques for analyzing multivariate data. Starts with a formulation of the population models, delineates the corresponding sample results, and liberally ...

Shakespeare's Richard III: Character Analysis |

Richard III is among Shakespeare's most frequently performed and studied plays and is regarded by many critics as a masterpiece due, in part, to how Shakespeare carries us into and through the ...

Shakespeare Resource Center - Speech Analysis: Richard III

Richard III "Now is the winter of our discontent...." Line Analysis | Readings Page | Home. Much has been made of Shakespeare's portrayal of Richard III and how the play and other Tudor-era writings have framed this oft-maligned monarch's brief reign. The opening speech to Richard III sets the tone from the first moment Richard enters the stage ...

Richard III Analysis | Shmoop

Having trouble understanding Richard III? Here's an in-depth analysis of the most important parts, in an easy-to-understand format.

Richard Unwin | The Art Newspaper

Richard Unwin Subscribe to The Art Newspaper’s digital newsletter for your daily digest of essential news, views and analysis from the international art world delivered directly to your inbox ...

Analysis of Richard Cory by Edwin Arlington Robinson

Richard Cory Analysis First Stanza. Whenever Richard Cory went down town, We people on the pavement looked at him: He was a gentleman from sole to crown, Clean-favoured, and imperially slim. This is our introduction to the eponymous character, Richard Cory. He is held in great esteem by the townspeople. This is clear as he attracts their attention for they ‘looked at him’ and noted that ...

Richard II: Study Guide | SparkNotes

Richard II is a play by William Shakespeare that was first performed in 1597. Summary Read a Plot Overview of the entire play or a scene by scene Summary and Analysis.

Richard III Act 1, Scene 1 Summary & Analysis | LitCharts

Richard of Gloucester enters alone and sets the scene, opening with one of Shakespeare's most famous lines: "Now is the winter of our discontent." Though it's technically summer, it is winter from Richard's perspective because he is unhappy. His family, the House of York, has emerged victorious from the Wars of the Roses and all around him people are celebrating and enjoying peacetime.

Shakespeare Resource Center - Line Analysis: Richard III

Richard hearkens back to the beginning of the speech to tie his disdain for peace in with his disdain for his stature. - / - / - / - / - / Have no delight to pass away the time, Because Richard is not suited for love by appearance or nature, he can indulge in none of the delights of peace. All this part of the speech is leading up to his ...

Shakespeare's Richard III - Character Analysis of ...

analysis: quotations: sources: biography: theatres: key dates: plots: faq: books: glossary: scholars: quiz: search : The Character of Richard III. An excerpt from Richard III. New York: University Society Press, 1901. The character of Richard the Third, which had been opened in so masterly a manner in the Concluding Part of Henry the Sixth, is, in this play, developed in all its horrible ...

Richard II Act 4, Scene 1 Summary & Analysis | LitCharts

Richard says that any outward showing of grief is just a shadow to the true, internal grief. Inside, says Richard, is where the true substance lies. After this speech, Richard asks to be taken away, just so that he doesn’t have to see Henry anymore; the old king is then taken to the tower, and most everyone exits.

Unwind Book Analysis - 769 Words | Cram

Unwind Book Analysis. 769 Words 4 Pages. Show More “The moment you’re loved, that's when you got your soul” (Shusterman 174). Neal Shusterman, the author of Unwind, grew up in Brooklyn, where he began writing at an early age. Shusterman wrote Unwind with the intention to “point out the fact that there are two sides on all of these gray area issues” (Shusterman); he wanted people to ...

Richard II Act 1 Summary and Analysis | GradeSaver

Analysis. One of the great ironies of Richard II is that Richard is unable to arbitrate the opening dispute since he is himself guilty of the crime. The Duke of Gloucester had been entrusted to Mowbray, but it is likely that Richard ordered Mowbray to kill the duke. Thus Mowbray cannot accuse the true culprit, and his understandably outraged at being called a traitor. The opening scene serves ...

Shakespeare, William - Richard III. - Inhalt und Analyse ...

Shakespeare, William - Richard III. - Inhalt und Analyse - Didaktik / Deutsch - Literatur, Werke - Referat 2001 - ebook 0,- € - GRIN

Richard UNWIN | Proteomics Lead and Honorary Lecturer ...

Richard UNWIN, Proteomics Lead and Honorary Lecturer of The University of Manchester, Manchester | Read 114 publications | Contact Richard UNWIN

Richard III - CliffsNotes

Character Analysis Lady Anne The widow of Edward, Prince of Wales, son of Henry VI, became the wretched wife of Richard of Gloucester. Prior to her appearance in Act I, Scene 2, it was from Richard himself that we learned of his villainy. Anne's first function, then, is to provide chapter and verse for Richard's villainy by excoriating him as ...

Solved: The Body Of Richard III Of England Has Recently Be ...

The body of Richard III of England has recently been identified through mitochondrial DNA analysis. The scientists involved in this project isolated mitochondrial DNA from the skeleton and also from a 17th generation descendent of Richard III’s sister. Explain, with the help of a genetic diagram, how the scientists used the DNA to prove that the skeleton belonged to Richard III. Represent ...

Richard Löwenherz – Wikipedia

Richard Löwenherz entstammte dem adligen Geschlecht der Plantagenets.Dieser Name wurde jedoch als Dynastiebezeichnung erst ab dem 15. Jahrhundert verwendet, erstmals 1460 durch Herzog Richard von York.Er geht auf König Richards Großvater Gottfried V. zurück, der Graf von Anjou, Tours und Maine war. Der Legende nach trug er einen Ginsterbusch (planta genista) als Helmzier oder pflanzte in ...

Richard Hamilton: Just what is it that makes today’s homes ...

Richard Hamilton hat seine Collage für diese Ausstellung geschaffen; sie diente zugleich als Titelbild für das Werbematerial zu der Veranstaltung. Aus dem Protest gegen den Mainstream entwickelte sich in den Sechzigerjahren selbst eine der bekanntesten und mächtigsten Kunstströmungen des 20. Jahrhundert, die Pop-Art. Vor allem die amerikanischen Vertreter der Pop-Art, die Rauschenberg ...

Gold: A near term unwind would help to renew upside ...

Richard Perry Hantec Markets Follow Following. Gold: A near term unwind would help to renew upside potential [Video] ANALYSIS | 7/10/2020 11:51:15 AM. Gold. After the breakout comes the pullback ...

Sachtextanalyse - stylistic devices: Liste

Bei der Analyse von Sachtexten (non-fictional texts) im Englischen gibt es spezielle rhetorische Mittel oder Stilmittel (stylistic devices), die du dir merken solltest.Hier findest du eine Liste der wichtigsten stylistic devices, die sich auf Sachtexte beziehen. Wir wollen dir erklären, welche stylistic devices es gibt und wie sie auf den Leser wirken bzw. wirken sollen.

The plot | Richard II | Royal Shakespeare Company

A story of power and plotting, Richard II is the first of Shakespeare's four plays about the House of Lancaster. In the presence of King Richard, Henry Bolingbroke (who would eventually be Henry IV) accuses Thomas Mowbray (Duke of Norfolk) of embezzling crown funds and of plotting the death of his uncle, the Duke of Gloucester. They will not be reconciled and are about to fight, but Richard ...

The Chart of the Week: EUR/USD's copy-book landing, still ...

In a copy-book landing, EUR/USD has played out exactly in accordance with the following weekly mini-series of bearish analysis: (13/09/2020) The Chart

Dehmel, Richard: Entbietung – Moderne

3 Analyse; 4 Stilzuordnung; 5 Literatur; 6 Autorin des Artikels; Autor. Richard Dehmel. Richard Dehmel war einer der berühmtesten deutschen Schriftsteller und Lyriker, vor dem Ersten Weltkrieg. Seiner Werke stehen zwischen Naturalismus und Impressionismus und spiegeln die Stilproblematik der Jahrhundertwende wieder. Als Sohn eines Försters wird Richard Fedor Leopold Dehmel am 18. November ...

Der Arbeitsmann von Richard Dehmel -

Gedicht-Analyse. Bei dem vorliegenden Text handelt es sich um das Gedicht „Der Arbeitsmann“ des Autors Richard Dehmel. Dehmel wurde im Jahr 1863 in Wendisch-Hermsdorf, Mark Brandenburg geboren. Im Zeitraum zwischen 1879 und 1920 ist das Gedicht entstanden. Die Entstehungszeit des Gedichtes bzw. die Lebensdaten des Autors lassen eine Zuordnung zur Epoche Moderne zu. Bei dem Schriftsteller ...

Zu Richard Strauss' "Alpensinfonie": "Anbetung der ewigen ...

Am 13. und 14. Oktober 2016 brachte Mariss Jansons mit dem Symphonieorchester des Bayerischen Rundfunks Richard Strauss' "Alpensinfonie" zur Aufführung. Das 1915 vollendete Werk hat seinen ...

Richard III Act 1 Summary and Analysis | GradeSaver

Analysis of Act One. Richard's opening soliloquy frames much of the play, and reveals a great deal about the personality of Richard's character. The opening remarks are very logical in their progression: because Richard is deformed, he cannot be loved; because he cannot be loved, he must be a villain; because he must be a villain, he will strive for the throne. This logical progression is of ...

30+ "Richard Unwin" profiles | LinkedIn

View the profiles of professionals named "Richard Unwin" on LinkedIn. There are 30+ professionals named "Richard Unwin", who use LinkedIn to exchange information, ideas, and opportunities.

Richard Unwin Profiles | Facebook

View the profiles of people named Richard Unwin. Join Facebook to connect with Richard Unwin and others you may know. Facebook gives people the power to...

Weizsäcker, Richard von - Der 8. Mai 1945 (40 Jahre danach ...

Weizsäcker, Richard von - Der 8. Mai 1945 (40 Jahre danach - Analyse der Kriegserinnerungsrede) - Referat : nicht vergessen. Keiner soll die Vergangenheit verdrängen, jeder soll sich mit ihr auseinandersetzen. Richard von Weizsäcker will den Leuten klar machen, dass sich so etwas leicht wiederholen kann. Gerade in der heutigen Zeit gibt es immer mehr rechtsextremistische und ...

Analysis: Labour's Richard Leonard, the invisible man of ...

The game is over. The rebels have lost. And so, the die is cast.Richard Leonard will lead Labour into the Holyrood elections, but few people are convinced that the party can hold on to either seats or

ANALYSE-FLASH: RBC hebt Ziel für H&M auf 175 Kronen ...

Aktien » Nachrichten » H&M AKTIE » ANALYSE-FLASH: RBC hebt Ziel für H&M auf 175 Kronen - 'Sector Perform' Push Mitteilungen FN als Startseite. H&M HENNES & MAURITZ AB WKN: 872318 ISIN ...

"Richard Cory" by Edwin Arlington Robinson: Poem Analysis ...

Analysis of "Richard Cory" Summary and Theme. A narrative poem, “Richard Cory” is the story of a man who seems to have it all. The people of the town, who are clearly of a lower financial class, place Richard Cory on a pedestal. They look up to him and want to be just like him. In the end, though, they learn a valuable life lesson: Richard Cory kills himself, showing the people of the town ...

Richard Serra | Inside Out (2013) | Artsy

From Gagosian, Richard Serra, Inside Out (2013), Weatherproof Steel, 158 × 982 × 482 1/2 in

Probe von Richard Löwenherz’ Herz analysiert

Nun ist das Analysieren vermutlicher royaler Überreste mithilfe modernster Technik gerade schwer in Mode. Die Universität Leicester hat vor ein paar Monaten unter einem Parkplatz gefundene Knochen per DNA-Test dem englischen König Richard III. zugeordnet, einem Nachfahren von Richard I. Löwenherz aus der Familie der Plantagenet.

UBS belässt Vivendi auf 'Buy' - Ziel 32 Euro

ZÜRICH (dpa-AFX Analyser) - Die Schweizer Großbank UBS hat die Einstufung für Vivendi auf 'Buy' mit einem Kursziel von 32 Euro belassen. Analyst Richard ...

Richards Karin (@Richards_Karin) • Twitter

Hier sollte eine Beschreibung angezeigt werden, diese Seite lässt dies jedoch nicht zu.

Richard Dehmel – Wikipedia

Richard Fedor Leopold Dehmel (* 18. November 1863 in Hermsdorf bei Wendisch Buchholz, Provinz Brandenburg (heute Ortsteil der Gemeinde Münchehofe); † 8. Februar 1920 in Blankenese) war ein deutscher Dichter und Schriftsteller. Richard Dehmel 1905 auf einer Fotografie von Rudolf Dührkoop. Richard Dehmel als Soldat im Ersten Weltkrieg. Hans Anetsberger Illustration zu Der Arbeitsmann, in ...

Richard Matthew Stallman (RMS) is Still Monitoring the ...

10.04.20 Richard Matthew Stallman (RMS) is Still Monitoring the Attacks on Software Freedom. Posted in Free/Libre Software, GNU/Linux, OSI at 9:33 am by Dr. Roy Schestowitz. Watching without saying much, for now… Summary: Richard Stallman (RMS) is exploring new ways to deal with new threats to software freedom, even if it’s done mostly behind the scenes (dodging those hyenas who defamed ...

Richard LWIN | The University of Sydney, Sydney

Richard LWIN of The University of Sydney, Sydney | Read 51 publications | Contact Richard LWIN

Richard von Weizsäcker und seine große Rede von 1985 ...

Richard von Weizsäcker beantwortete diese Frage mutig und direkt. Indem er die Lesart des Datums veränderte. Der Präsident deklarierte den 8. Mai zum "Tag der Befreiung". Und Weizsäcker ...

Richard Stallman to Give a Talk at the FSF’s Anniversary ...

Richard Stallman (RMS) does not or has not appeared much in public this year (partly because of the pandemic), but he’s still keeping busy, writing articles, doing TV interviews, and soon speaking at the FSF’s coral anniversary; his latest article focuses on ethics associated with Clown Computing-type disservices and blackbox appliances

Richard Long und sein Beitrag zur ´Land Art´ - GRIN

Richard Long und sein Beitrag zur ´Land Art´ - Kunst / Installationen, Aktionskunst, 'moderne' Kunst - Examensarbeit 2004 - ebook 20,99 € - GRIN

Siegfried Handlung – Richard Wagner Libretto & Leitmotive

ERSTER AUFZUG Szene eins Eine Schmiedewerkstatt im Wald. Mime schmiedet ein Schwert, mit dem Siegfried einst Fafner erschlagen soll ("Zwangvolle Plage! Müh' ohne Zweck!"). Mime will so in den Besitz des Ringes zu gelangen, den Fafner hütet. Der junge Siegfried stürmt herein. Als er zurückkommt, führt er einen Bären mit sich. Siegfried zerschlägt das neu geschmiedete…

Группа авторов Protein Interactions

The interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design. This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules. Contents: Protein–Protein Interactions: Structural and Dynamical Aspects of Evolutionarily Conserved Protein–Protein Complexes (Himani Tandon, Sneha Vishwanath and Narayanaswamy Srinivasan) A Comprehensive Overview of Sequence-Based Protein-Binding Residue Predictions for Structured and Disordered Regions (Amita Barik and Lukasz Kurgan) Prediction of Protein–Protein Complex Structures by Docking (Danial Pourjafar-Dehkordi and Martin Zacharias) Binding Affinity of Protein–Protein Complexes: Experimental Techniques, Databases and Computational Methods (M Michael Gromiha) Mutational Effects on Protein–Protein Interactions (Jackson Weako, Attila Gursoy and Ozlem Keskin) Predicting the Consequences of Mutations (Hemant Kumar and Julia M Shifman) Protein–Nucleic Acid Interactions: Computational Approaches for Understanding the Recognition Mechanism of Protein–Nucleic Acid Complexes (Ambuj Srivastava, Dhanusha Yesudhas, A Kulandaisamy, Nisha Muralidharan, C Ramakrishnan, R Nagarajan and M Michael Gromiha) Prediction of Nucleic Acid Binding Proteins and Their Binding Sites (Dhanusha Yesudhas, Ambuj Srivastava, Nisha Muralidharan, A Kulandaisamy, R Nagarajan and M Michael Gromiha) Predicting Protein–Binding Sites in Nucleic Acids (Kyungsook Han) Docking Algorithms and Scoring Functions (Arina Afanasyeva, Chioko Nagao and Kenji Mizuguchi) Recent Progress of Methodology Development for Protein–RNA Docking (Yun Guo, Xiaoyong Pan and Hong-Bin Shen) Protein–Ligand Interactions: Protein–Carbohydrate Complexes: Binding Site Analysis, Prediction, Binding Affinity and Molecular Dynamics Simulations (K Veluraja, N R Siva Shanmugam, J Jino Blessy, R A Jeyaram, B Lalithamaheswari and M Michael Gromiha) Quantitative Structure-Activity Relationship in Ligand-Based Drug Design: Concepts and Applications (Vishnupriya Kanakaveti, P Anoosha, R Sakthivel, S K Rayala and M Michael Gromiha) Protein–Ligand Interactions in Molecular Modeling and Structure-Based Drug Design (Devadasan Velmurugan, Dasararaju Gayathri, Chandrasekaran Ramakrishnan and Atanu Bhattacharjee) An Overview of Protein–Ligand Docking and Scoring Algorithms (Ruchika Bhat, Abhilash Jayaraj, Anjali Soni and B Jayaram) Readership: Graduate students and researchers working on protein interactions; researchers in the fields of bioinformatics, computational biology, computational chemistry, biochemistry, biophysics.Protein Interactions;Binding Sites;Prediction;Structural Analysis;Recognition Mechanism;Computational Methods;Protein-protein;Protein-RNA;Protein-DNA;Protein-ligand;Binding Affinity;Mutation;Databases;Web Servers;QSAR;Docking;Molecular Dynamics;Drug Design0 Key Features: Single unique source with concepts and applications on all types of protein complexesWritten by outstanding researchers in the field with easily understandable illustrationsCompilation of databases and online toolsUp-to-date literature and latest developments

9214.87 RUR

/ / похожие


Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways

16934.89 RUR

/ / похожие


Uversky Vladimir Instrumental Analysis of Intrinsically Disordered Proteins. Assessing Structure and Conformation

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

17055.31 RUR

/ / похожие


Richard Razgaitis Dealmaking. Using Real Options and Monte Carlo Analysis

Applying practical tools to the volatile process of negotiating Prognosticators apply Monte Carlo Analysis (MCA) to determine the likelihood and significance of a complete range of future outcomes; Real Options Analysis (ROA) can then be employed to develop pricing structures, or options, for such outcomes. Richard Razgaitis' Dealmaking shows readers how to apply these powerful valuation tools to a variety of business processes, such as pricing, negotiating, or living with a «deal,» be it a technology license, and R&D partnership, or an outright sales agreement. Dealmaking distinguishes itself from other negotiating guides not only by treating negotiations as an increasingly common situation, but also by presenting a tool-based approach that creates flexible, practical valuation models. This forward-thinking guide includes a variety of checklists, case studies, and a CD-ROM with the appropriate software. Richard Razgaitis (Bloomsbury, NJ) is a Managing Director at InteCap, Inc. He has over twenty-five years of experience working with the development, commercialization, and strategic management of technology, seventeen of which have been spent in the commercialization of intellectual property.

4837.81 RUR

/ / похожие


Dev Kambhampati Protein Microarray Technology

This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.

18737.42 RUR

/ / похожие


Thomas Luetteke Bioinformatics for Glycobiology and Glycomics. An Introduction

This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

19155.84 RUR

/ / похожие


Hugo Kubinyi Protein-Protein Interactions in Drug Discovery

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach. From the contents: * Prediction of intra- and inter-species protein-protein interactions facilitating systems biology studies * Modulators of protein-protein interactions: The importance of Three-Dimensionality * Interactive technologies for leveraging the known chemistry of anchor residues * SH3 Domains as Drug Targets * P53 MDM2 Antagonists: Towards Non Genotoxic Anticancer Treatments * Inhibition of LFA-1/ICAM interaction for treatment of autoimmune diseases * The PIF-binding pocket of AGC kinases * Peptidic inhibitors of protein-protein interactions for cell adhesion receptors * The REPLACE Strategy for generating Non-ATP competitive Inhibitors of Cell-Cycle Protein Kinases and more

20321.87 RUR

/ / похожие


David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications

Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) – a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.

12096.35 RUR

/ / похожие


Richard Tinder Asynchronous Sequential Machine Design and Analysis

Richard A Frazier Capillary Electrophoresis for Food Analysis — Каталог цен и описаний на компьютерную и бытовую технику, товары для офис и дома, электронику, товаров для сада и дачи. Мы занимаемся поиском лучших цен в интернет магазинах по всей России, знаем где купить Richard Unwin D Analysis of Protein по оптимальной цене в онлайн-магазинах. На нашем сайте предоставлена вся необходимая информация для правильной покупки Richard Unwin D Analysis of Protein — фотографии товаров, отзывы пользователей, поиск по модели и производителю, наименованию или модели, инструкции по эксплуатации, а так же экспертные обзоры, сайты предлагающие покупу онлайн с доставкой заказа в ваш город.